Conservation of estrogen receptor function in invertebrate reproduction.

摘要: Rotifers are microscopic aquatic invertebrates that reproduce both sexually and asexually. Though rotifers phylogenetically distant from humans, have specialized reproductive physiology, this work identifies a surprising conservation in the control of reproduction between humans through estrogen receptor. Until recently, steroid signaling has been observed only few invertebrate taxa its role regulating not clearly demonstrated. Insights into evolution sex pathways can be gained by clarifying how receptors function reproduction. In paper, we show ligand-activated estrogen-like receptor binds human estradiol regulates output females. other characterized thus far, ER ligand binding domains occluded ligand-binding sites ERs activated. We used suite computational, biochemical biological techniques to determine rotifer site is bind estradiol. Our results demonstrate mammalian hormone plays key ancient microinvertebrate Brachinous manjavacas. The presence activity within phylum Rotifera indicates structure highly conserved throughout animal evolution.