Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

摘要: Neurons have more extended and complex shapes than other cells consequently face a greater challenge in distributing maintaining mitochondria throughout their arbors. can last lifetime, but proteins turn over rapidly. Mitochondria, therefore, need constant rejuvenation no matter how far they are from the soma. Axonal transport of mitochondrial fission fusion contribute to this rejuvenation, local protein synthesis is also likely. Maintenance healthy population requires clearance damaged organelles. This involves degradation individual proteins, sequestration mitochondria-derived vesicles, organelle by mitophagy macroautophagy, some cases transfer glial cells. Both long-range processing thus at work achieving neuronal mitostasis-the maintenance an appropriately distributed pool for duration neuron's life. Accordingly, defects processes that support mitostasis significant contributors neurodegenerative disorders.