High Dietary Acid Load Predicts ESRD among Adults with CKD

摘要: Small clinical trials have shown that a reduction in dietary acid load (DAL) improves kidney injury and slows function decline; however, the relationship between DAL risk of ESRD population-based cohort with CKD remains unexamined. We examined association DAL, quantified by net excretion (NAE es ), progression to nationally representative sample adults United States. Among 1486 age≥20 years enrolled National Health Nutrition Examination Survey III, was determined 24-h recall questionnaire. The development ascertained over median 14.2 follow-up through linkage Medicare Registry. used Fine–Gray competing risks method estimate high, medium, low after adjusting for demographics, nutritional factors, function/damage markers accounting intervening mortality events. In total, 311 (20.9%) participants developed ESRD. Higher levels were associated increased ESRD; relative hazards (95% confidence interval) 3.04 (1.58 5.86) highest tertile 1.81 (0.89 3.68) middle compared lowest fully adjusted model. tertiles as eGFR decreased ( P trend = 0.001). albuminuria, high strongly trend=0.03). conclusion, persons is independently population.