Nerve growth factor function in the central nervous system.

摘要: A complete understanding of NGF function in the CNS does not exist. Instead, there is a collection observations based on experiments conducted PNS and CNS, although more definitive results have come from PNS. The conclusion that neurotropic factor biased experimental design interpretation when for was sought. An example bias very significant paper by Schwab et al. (1979), showing first time retrograde transport cholinergic neurons. These authors entitled manuscript “Nerve growth (NGF) CNS: absence specific tyrosine hydroxylase induction locus coeruleus substantia nigra”, documenting expectation catecholamine neurons as Subsequent experiments, reviewed here, support neurotrophic role rather than catecholaminergic system