Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors

摘要: Radiological examination may unexpectedly reveal an adrenal mass. Current algorithms for differentiating between benign and malignant lesions mainly rely on size densitometry unenhanced CT, which have limited specificity. We examined the diagnostic value of urinary steroid profiling by gas chromatography/mass-spectrometry (GC/MS) in tumors. A retrospective study two referral centers patients with disease was performed. All profiles ordered evaluation tumor January 2000 November 2011 were examined. Patients diagnosed cortical carcinoma (ACC), adenoma (ACA), or other Results hormonal measurements, imaging studies, pathology reports, clinical outcome retrieved from medical records. The individual metabolites determined receiver operating characteristics analysis. Cut-off values compared to reference age gender-standardized population healthy controls. Eighteen excreted significantly higher concentrations ACC (n = 27) ACA (n = 107) conditions (n = 18). Tetrahydro-11-deoxycortisol (THS) at a cut-off 2.35 μmol/24 h differentiated disorders 100 % sensitivity 99 % Elevated excretion THS associated very high specificity differentiate Urinary might be useful test incidentaloma.