Evolution of Computed Tomography Angiography Spot Sign Is Consistent With a Site of Active Hemorrhage in Acute Intracerebral Hemorrhage

作者: Dar Dowlatshahi , Jason K. Wasserman , Franco Momoli , William Petrcich , Grant Stotts

DOI: 10.1161/STROKEAHA.113.003387

关键词: FibrinRadiologyAcquisition ProtocolHematomaMedicineAngiographyComputed tomography angiographySpot signExtravasationIntracerebral hemorrhage

摘要: Background and Purpose—CT angiography spot sign predicts hematoma expansion in patients with acute intracerebral hemorrhage (ICH). The may represent a site of active extravasation, locus arrested forming fibrin globes, or associated epiphenomena such as hypertensive microaneurysms. We sought to describe the evolution signs over 60 seconds ICH using dynamic CT determine whether they grow diffuse into would be expected extravasation. Methods—We prospectively identified consecutive presenting spontaneous <6 hours from symptom onset that completed imaging 60-second acquisition protocol. determined positivity, quantified volumes, then used repeated-measures ANOVA assess changes volume time. Results—We collected data on 35 patients; 13 (37%) were spot-positive. Spot-positive had larger median compa...

参考文章(15)
Fisher Cm, Cerebral Miliary Aneurysms in Hypertension American Journal of Pathology. ,vol. 66, pp. 313- 330 ,(1972)
Dar Dowlatshahi, Jayme C. Kosior, Sherif Idris, Muneer Eesa, Peter Dickhoff, Manish Joshi, Suresh Subramaniam, Sarah Tymchuk, Michael D. Hill, Richard I. Aviv, Richard Frayne, Andrew M. Demchuk, Planimetric Hematoma Measurement in Patients With Intraventricular Hemorrhage Stroke. ,vol. 43, pp. 1961- 1963 ,(2012) , 10.1161/STROKEAHA.112.654970
Sheng-Jun Sun, Pei-Yi Gao, Bin-Bin Sui, Xin-Yi Hou, Yan Lin, Jing Xue, Ren-You Zhai, "Dynamic spot sign" on CT perfusion source images predicts haematoma expansion in acute intracerebral haemorrhage. European Radiology. ,vol. 23, pp. 1846- 1854 ,(2013) , 10.1007/S00330-013-2803-4
Y. Murai, Y. Ikeda, A. Teramoto, J. N. Goldstein, S. M. Greenberg, E. E. Smith, M. H. Lev, J. Rosand, CONTRAST EXTRAVASATION ON CT ANGIOGRAPHY PREDICTS HEMATOMA EXPANSION IN INTRACEREBRAL HEMORRHAGE Neurology. ,vol. 68, pp. 889- 894 ,(2007) , 10.1212/01.WNL.0000278894.44311.0B
Andrew M Demchuk, Dar Dowlatshahi, David Rodriguez-Luna, Carlos A Molina, Yolanda Silva Blas, Imanuel Dzialowski, Adam Kobayashi, Jean-Martin Boulanger, Cheemun Lum, Gord Gubitz, Vasantha Padma, Jayanta Roy, Carlos S Kase, Jayme Kosior, Rohit Bhatia, Sarah Tymchuk, Suresh Subramaniam, David J Gladstone, Michael D Hill, Richard I Aviv, Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurology. ,vol. 11, pp. 307- 314 ,(2012) , 10.1016/S1474-4422(12)70038-8
S. M. Davis, J. Broderick, M. Hennerici, N. C. Brun, M. N. Diringer, S. A. Mayer, K. Begtrup, T. Steiner, , Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage Neurology. ,vol. 66, pp. 1175- 1181 ,(2006) , 10.1212/01.WNL.0000208408.98482.99
Ryan Wada, Richard I. Aviv, Allan J. Fox, Demetrios J. Sahlas, David J. Gladstone, George Tomlinson, Sean P. Symons, CT Angiography “Spot Sign” Predicts Hematoma Expansion in Acute Intracerebral Hemorrhage Stroke. ,vol. 38, pp. 1257- 1262 ,(2007) , 10.1161/01.STR.0000259633.59404.F3
Thien J. Huynh, Andrew M. Demchuk, Dar Dowlatshahi, David J. Gladstone, Özlem Krischek, Alex Kiss, Michael D. Hill, Carlos A. Molina, David Rodriguez-Luna, Imanuel Dzialowski, Yolanda Silva, Anna Czlonkowska, Cheemun Lum, Jean-Martin Boulanger, Gord Gubitz, Rohit Bhatia, Vasantha Padma, Jayanta Roy, Carlos S. Kase, Richard I. Aviv, Spot Sign Number Is the Most Important Spot Sign Characteristic for Predicting Hematoma Expansion Using First-Pass Computed Tomography Angiography Analysis From the PREDICT Study Stroke. ,vol. 44, pp. 972- 977 ,(2013) , 10.1161/STROKEAHA.111.000410
S Chakraborty, D Blacquiere, C Lum, G Stotts, Dynamic nature of the CT angiographic “spot sign” British Journal of Radiology. ,vol. 83, ,(2010) , 10.1259/BJR/74416385
C.D. d'Esterre, T.L. Chia, A. Jairath, T.Y. Lee, S.P. Symons, R.I. Aviv, Early rate of contrast extravasation in patients with intracerebral hemorrhage. American Journal of Neuroradiology. ,vol. 32, pp. 1879- 1884 ,(2011) , 10.3174/AJNR.A2669