Landscape genetics highlights the role of bank vole metapopulation dynamics in the epidemiology of Puumala hantavirus

摘要: Rodent host dynamics and dispersal are thought to be critical for hantavirus epidemiology as they determine pathogen persistence transmission within between populations. We used landscape genetics investigate how the population of bank vole Myodes glareolus, Puumala (PUUV), vary with forest fragmentation influence PUUV epidemiology. sampled populations Ardennes, a French endemic area. inferred demographic features such size, isolation migration regard configuration. next analysed M. glareolus on spatial distribution. Our results revealed that global metapopulation voles were strongly shaped by features, including suitable patch size connectivity. Large effective in might therefore contribute higher observed levels prevalence. By contrast, from hedge networks highly suffered genetic drift appeared isolated all other This result high probabilities local extinction both PUUV. Besides, we detected signatures asymmetric forests hedges. These movements likely sustain fragmented landscapes. In conclusion, our study provided arguments favour source-sink shaping spread heterogeneous, Western European temperate It illustrated potential contribution understanding epidemiological processes occurring at this scale.