Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease.

摘要: Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within substantia nigra is further increased, contributing to a heightened pro-oxidant environment dopaminergic neurons. We hypothesise that individuals high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life exposure predisposes them age-related accumulation Combined genetic factors limit regulatory capacity and/or dopamine metabolism, this may increase risk of diseases. propose (a) validate retrospective biomarker children; (b) translate adults; (c) integrate it vivo brain disease; (d) longitudinally examine relationships between disease risk. This approach will provide empirical evidence support therapeutically addressing diseases produce potential preclinical individuals.