The Role of JNK Signalling in Responses to Oxidative DNA Damage.

摘要: The production of reactive oxygen species is a normal part cell physiology, but many internal and external stimuli are able to trigger the excess levels oxidants that potentially damaging. threat oxidative damage particularly significant DNA, as damaged bases can interfere with replication generate lasting mutations. Signalling through JNK pathway key cellular response damage. Depending on intensity duration signal, signalling lead distinct alternative responses including DNA repair, anti-oxidant or death. These highly relevant cancer therapy, tumours often under stress produces elevated therapy involves inducing intention driving In this review we examine causes consequences activation relate damage, focus potential therapeutic implications.