Optical measurements of extracellular calcium depletion during a single heartbeat.

作者: L Cleemann , G Pizarro , M Morad

DOI: 10.1126/SCIENCE.6091269

关键词: SarcolemmaEndocrinologyMembrane potentialT-type calcium channelElectrophysiologyChemistryCalciumCardiac action potentialExtracellularCalcium ATPaseInternal medicineBiophysics

摘要: The impermeant dye antipyrylazo III was used to measure depletion of extracellular calcium and net influx through the sarcolemma during cardiac action potential. It found that entry occurs continuously potential is under direct control membrane inotropic epinephrine accompanied by increased calcium, while strophanthidin enhances twitch without altering

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