The effect of portal hypertension on indomethacin-induced small intestinal ulceration in the rat.
作者： G. M. JONAS , R. A. ERICKSON , K. CHUNG
DOI: 10.1111/J.1365-2036.1991.TB00004.X
关键词: Portal vein ligation 、 Gastroenterology 、 Medicine 、 INTESTINAL ULCERATION 、 Toxicity 、 Small intestine 、 Internal medicine 、 Ligation 、 Portal vein 、 Portal hypertension
摘要: SUMMARY The purpose of this study was to determine whether portal hypertension potentiates intestinal ulceration induced by indomethacin. Portal produced in male Sprague-Dawley rats two-staged ligation the vein. Sham-operated were used as controls. The given 20 mg/kg indomethacin intragastrically, 7 and 14 days, respectively, after complete vein ligation. Forty-eight 72 h indomethacin, pressures measured whole small intestine removed for quantitative measurement percent mucosa ulcerated computerized image analysis. There no differences area between hypertensive sham-operated at either or despite presence significant hypertension. does not appear potentiate rats.
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