Early parent–child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16‐year prospective cohort study

摘要: Aim Exposure to parental bipolar disorder (BD) early in life may increase the risk of developing a mood disorder. However, impact parent–child relationships when parent is affected and how this impacts an offspring's remains unclear. The primary objective study was determine association between offspring parents with BD and, secondly, interaction temperament stress on association. Methods Two hundred thirty-three completed annual clinical assessments following Kiddie Schedule for Affective Disorders (KSADS) format interviews as part ongoing Canadian prospective cohort conducted from 1996 2013. Offspring measures adversity, temperament. Clinical data were prospectively collected over first decade their using SADS interviews. Results Higher perceived neglect mother emotionality significantly associated hazard (hazard ratio (HR): 1.1, 95% confidence interval (CI): 1.0–1.2 HR: 1.7, CI: 1.0–3.1, respectively). Duration exposure interacted predict (P = 0.01). Further, high (P = 0.02). Conclusions Neglect significant predictor at familial emotional sensitivity. Psychosocial support interventions high-risk families could be beneficial reducing maternal subsequent disorders offspring.