Clock genes and cancer development in particular in endocrine tissues

摘要: Circadian rhythms at a central and peripheral level are operated by transcriptional/translational feedback loops involving set of genes called 'clock genes' that have been implicated in the development several diseases, including malignancies. Dysregulation Clock system can influence cancer susceptibility regulating DNA damage repair mechanisms, as well apoptosis. A number oncogenic pathways be dysregulated via clock epigenetic alterations, hypermethylation promoters or variants genes. gene disruption has studied breast, lung prostate cancer, haematological However, it is still not entirely clear whether cause consequence tumourigenesis data endocrine neoplasms scarce. Recent findings suggest benign malignant adrenocortical neoplasias. They also associated with follicular papillary thyroid carcinomas parathyroid adenomas, pituitary adenomas craniopharyngiomas. encountered ovarian testicular tumours may related their to chemotherapeutic agents. The most common PER1, CRY1; cases expression downregulated tumoural compared normal tissues. Although there lot done for better understanding role tumourigenenesis, existing evidence could guide research help identify novel therapeutic targets aiming mainly components system.