Drugs affecting lipid metabolism

摘要: Publisher Summary This chapter discusses several drugs that affect lipid metabolism. Adverse events are essentially the same with all fibrates. During short-term treatment, they generally mild or absent. The long-term effects still uncertain. Fibrates produce bile is supersaturated cholesterol. Although gallstones frequently seen clofibrate, no excess frequency has been observed fenofibrate. However, individuals liver disease of any type should probably not be advised to take In study discussed in chapter, hypoglycemia a diabetic patient apparently resulted from glyburide combined gemfibrozil. Because fibrates highly bound serum albumin, displace other similarly drugs. Constipation, upper abdominal pain, flatulence, heartburn, and nausea have various degrees. Vitamin K deficiency may theory lead hypoprothrombinemia hence bleeding. A degree osteoporosis osteomalacia can occur because reduced vitamin D absorption. Binding substances present gastrointestinal tract explains interactions cholestyramine, it special importance as concerns K, D, iron. It entirely clear what extent incidence adverse reactions nicotinic acid (niacin) encountered its derivatives. Flushing skin normal reaction high doses until tolerance develops. Some patients experience much more severe vascular sensations heat, throbbing headache, vertigo, faintness, and, sometimes, marked fall blood pressure.