Copper-promoted coupling of vinyl boronates and alcohols: a mild synthesis of allyl vinyl ethers.

摘要: A copper-promoted coupling of vinyl pinacol boronate esters and alcohols for the synthesis enol ethers is reported. The reaction occurs in 50−99% yield compatible with a variety functional groups. Cupric acetate copper source, triethylamine buffer used to prevent protodeboration; at room temperature. In addition excellent chemoselectivity, stereospecific.