Adrenal suppression following low-dose topical clobetasol propionate.

摘要: The use of topical steroids is associated with adverse systemic effects such as suppression the hypothalamic-pituitary-adrenal (HPA) axis, and application more than 50 g per week clobetasol propionate cream has been shown to cause secondary adrenal failure. We describe 4 patients who used over a prolonged period; 3 less (7.5, 25 30 week) yet all developed failure for up months after cessation therapy. Adrenal insufficiency following in moderate dosages may therefore be common previously recognized. It suggested that metyrapone test, which conveniently examines entire HPA should employed receiving long-term glucocorticoid supplementation given during episodes stress, infections surgery,