Evaluation of antioxidative and antitumor activities of extracted flavonoids from Pink Lady apples in human colon and breast cancer cell lines.
作者： Shufang Yang , Haisheng Zhang , Xingbin Yang , Yilin Zhu , Min Zhang
DOI: 10.1039/C5FO00570A
关键词: Botany 、 Pink lady 、 Cell growth 、 Pharmacology 、 Breast cancer 、 In vitro 、 Biology 、 Apoptosis 、 Cancer cell 、 Reactive oxygen species 、 Cell culture
摘要: The antioxidative and anticancer effects of extracted flavonoids from Pink Lady apples on human colon cancer LoVo cells breast MCF-7 were evaluated. It was found that the property peel-flavonoids (Peel-F) more effective than flesh-flavonoids (Flesh-F). Meanwhile, both Peel-F Flesh-F can inhibit cell growth in a dose-dependent manner, with IC50 values 110.33 ± 2.52 mg mL(-1) 378.14 1.64 for 58.42 1.39 296.06 3.71 cells. This led to conclusion against Flesh-F, scavenging ROS significantly higher vitro. Moreover, we also generation is critical mediator apple flavonoid-induced apoptosis induction effect Flesh-F.
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