Uridine diphosphate derivatives, compositions and methods for treating neurodegenerative disorders
作者： Philip G. Haydon , Raquel Revilla-Sanchez , Stephen Moss , Jinghui Dong , Jinbo Lee
DOI:
关键词: Cns injury 、 Receptor 、 Chemistry 、 Uridine diphosphate 、 Pharmacology
摘要: This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods using or in treating disorders that are responsive ligands, such as agonists, P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative (e.g., Alzheimer's disease) traumatic CNS injury, well pain.
lens.org 参考文章(81)
Mario Materazzi, Vincenzo Politi, Cinzia Piazza, Therapeutic active agent for treatment of neuron degenerative diseases ,(1997)
William E. Klunk, Brian J. Bacskai, Chester A. Mathis, Stephen T. Kajdasz, Megan E. McLellan, Matthew P. Frosch, Manik L. Debnath, Daniel P. Holt, Yanming Wang, Bradley T. Hyman, Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy-X04, a Systemically Administered Congo Red Derivative Journal of Neuropathology and Experimental Neurology. ,vol. 61, pp. 797- 805 ,(2002) , 10.1093/JNEN/61.9.797
Animal Models of Cognitive Impairment CRC Press. ,(2006) , 10.1201/9781420004335
Carol Watkins, Richard J. Wurtman, Methods for increasing blood cytidine and/or uridine levels and treating cytidine-dependent human diseases ,(1999)
Harvey F. Lodish, Molecular Cell Biology ,(1986)
Brian J. Bacskai, Stephen T. Kajdasz, Richard H. Christie, Cordelia Carter, Dora Games, Peter Seubert, Dale Schenk, Bradley T. Hyman, Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Medicine. ,vol. 7, pp. 369- 372 ,(2001) , 10.1038/85525
Seong G Kim, Zhan-Guo Gao, Kelly A Soltysiak, Tong-Shin Chang, Chaya Brodie, Kenneth A Jacobson, P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis. Cellular and Molecular Neurobiology. ,vol. 23, pp. 401- 418 ,(2003) , 10.1023/A:1023696806609
Brian J. Bacskai, Stephen T. Kajdasz, Megan E. McLellan, Dora Games, Peter Seubert, Dale Schenk, Bradley T. Hyman, Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-β In Vivo by Immunotherapy The Journal of Neuroscience. ,vol. 22, pp. 7873- 7878 ,(2002) , 10.1523/JNEUROSCI.22-18-07873.2002
Muthusamy Jayraman, Muthiah Manoharan, K. Narayanannair Jayaprakash, Rajendra K. Pandey, Shigeo Matsuda, David Butler, Kallanthottathil G. Rajeev, Chang Geng Peng, Takeshi Yamada, Chemical modifications of monomers and oligonucleotides with cycloaddition ,(2009)
Lisa A. Teather, Richard Wurtman, Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same ,(2007)