Expression of a disintegrin-like protein in cultured human vascular cells and in vivo
作者： Barbara Herren , Elaine W. Raines , Russell Ross
DOI: 10.1096/FASEBJ.11.2.9039960
关键词: ADAM15 、 In vivo 、 Chemistry 、 Platelet-derived growth factor receptor 、 Immunology 、 Umbilical vein 、 Endothelium 、 Cell 、 Cell biology 、 Disintegrin 、 Extracellular
摘要: Metalloproteinase-like, disintegrin-like, and cysteine-rich proteins (MDCs) are potential novel regulators of cell-cell cell-matrix interactions, as well matrix degradation. We have asked whether MDCs expressed in cultured diploid vascular cells, identified MDC 15 human aortic smooth muscle (SMC) umbilical vein endothelium (HUVEC). mRNA is at higher levels HUVECs than SMCs. In SMCs, not regulated by PDGF or IGF-I adherence to different extracellular matrices. Nor regulation observed HUVEC monolayers cell densities, after multi-scratch wounding, treatment with TNF-alpha, LPS, thrombin. However, differences proteolytic processing strains. contrast arterial protein vivo normal vessels, but up-regulated lesions atherosclerosis. These findings suggest that m...
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