Programmable One-Pot Glycosylation

摘要: In oligosaccharide synthesis, protecting groups, possible participating promoters/catalysts, reaction conditions, and donor leaving groups acceptors must all be carefully designed in order to generate the correct regio- stereochemistry for new glycosidic bond. Programmable one-pot synthesis has been developed address above problems. This strategy is based on sequential use of thioglycoside building blocks form bonds reactivity difference blocks. The activation anomeric group can attenuated through modification neighboring participation. reactivity-based applied glycosylation reactions where a series with identical react sequentially one vessel without laborious intermediate purification steps. It provides rapid access oligosaccharides wide-range molecular diversity. this chapter we outline recent development that synthesize wide variety glycoconjugates are associated infectious diseases or carbohydrate-based cancer antigens.