Enantiomerically Pure Epoxychromans via Asymmetric Catalysis
作者： Nam Ho Lee , Alexander R. Muci , Eric N. Jacobsen
DOI: 10.1016/S0040-4039(00)93426-9
关键词: Organic chemistry 、 Catalysis 、 Chemistry 、 Enantioselective synthesis
摘要: Abstract A practical and highly effective process for the asymmetric epoxidation of several 2,2-dimethylchromene derivatives is reported. Catalysis by Mn(salen) complex 4 in all cases affords epoxychromans with >90% ee, this method has been applied to synthesis two recently developed antihypertensive agents enantiomerically pure form.
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