Visible Light-Induced Photoredox Construction of Trifluoromethylated Quaternary Carbon Centers from Trifluoromethylated Tertiary Bromides.
作者： Feng Huan , Qing-Yun Chen , Yong Guo
关键词: Catalysis 、 Chemistry 、 Visible spectrum 、 Quaternary carbon 、 Oxidation reduction 、 Addition reaction 、 Nuclear magnetic resonance spectroscopy 、 Organic chemistry 、 Polymer chemistry
摘要: A mild, operationally simple, visible light-induced photoredox method for constructing novel trifluoromethylated quaternary carbon centers from tertiary bromides has been developed. Using this method, a wide range of alkenes were successfully bifunctionalized to γ-butyrolactams. As electron-rich alkenes, reactions catalyzed by Ir(dF(CF3)ppy)2(dtbbpy)(PF6) kinetic processes with high yields and short times. For styrenes, Ir(ppy)2(dtbbpy)(PF6) thermodynamic moderate prolonged reaction aliphatic the neither nor fac-Ir(ppy)3 was used as catalyst. Thus, not efficient alkenes. The atom-transfer radical addition alkynes also achieved. configuration products we separated E type only. Some exhibited bactericidal activity.
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