Monohydrate of (1-{9-[4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide
作者： Elfatih Elzein , Robert Seemayer , Jeff Zablocki , Travis Lemons
DOI:
关键词: Hydroxymethyl 、 Adenosine receptor 、 Chemistry 、 Stereochemistry
摘要: Disclosed is a synthesis suitable for large scale manufacture of an A 2A -adenosine receptor agonist, namely, (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide. Also, disclosed are polymorphs this compound and methods isolating specific polymorph. pharmaceutical compositions preparing compositions.
google.co.in 参考文章(136)
Claudia Kusmic, Luiz Belardinelli, Gianmario Sambuceti, Flavio Coceani, Arvinder Dhalla, Antonio L'Abbate, Coronary microcirculatory vasoconstriction induced by low-flow ischemia in mouse hearts is reversed by an A2A adenosine receptor agonist The FASEB Journal. ,vol. 21, ,(2007)
David G. Steer, Stephen Mccann, Dongsheng Yu, Method of registering devices ,(2010)
Andrejus Korolkovas, Essentials of molecular pharmacology : background for drug design Wiley-Interscience. ,(1970)
Julius Diamond, Xanthine compounds and method of treating bronchospastic and allergic diseases ,(1976)
Jr. Lawrence J. Carmon, Plating barrel door apparatus ,(1986)
David Shealy, Don Edgar Griswold, George A. Heavner, Li Li, Asthma-related anti-il-13 immunoglobulin derived proteins, compositions, methods and uses ,(2003)
Venkata P. Palle, Elfatih O. Elzein, Jeff A. Zablocki, 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists ,(2000)
RYUJI MARUMOTO, YOSHIO YOSHIOKA, OSAMU MIYASHITA, SHUNSUKE SHIMA, KINICHI IMAI, KATSUYOSHI KAWAZOE, MIKIO HONJO, Synthesis and coronary vasodilating activity of 2-substituted adenosines. Chemical & Pharmaceutical Bulletin. ,vol. 23, pp. 759- 774 ,(1975) , 10.1248/CPB.23.759
Richard J. Barrett, Method of detecting myocardial dysfunction in patients having a history of asthma or bronchospasm ,(2006)