Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression.
作者： Marion Wobser , Heike Voigt , Roland Houben , Andreas O. Eggert , Matthias Freiwald
DOI: 10.1007/S00262-006-0256-1
关键词: In vivo 、 Tryptophan 、 Immunotherapy 、 Dendritic cell 、 Indoleamine 2,3-dioxygenase 、 Immunology 、 Enzyme 、 Downregulation and upregulation 、 Cancer research 、 Biology 、 In vitro maturation
摘要: Background Recent reports have demonstrated that the enzyme indoleamine 2,3-dioxygenase (IDO) is upregulated in human dendritic cells (DCs) upon vitro maturation. IDO supposed to convey immunosuppressive effects by degrading essential amino acid tryptophan, thereby downregulating T-cell functions. Hence, we evaluated expression DC preparations used for therapeutic vaccination and its vivo effects.
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