Synthetic Biology-Empowered Hydrogels for Medical Diagnostics.

作者: Wilfried Weber , Hanna J. Wagner , Hasti Mohsenin

DOI: 10.1007/10_2020_158

关键词: AnalyticsBiochemical engineeringToolboxSynthetic biologyBiomedicineNetwork topologyMedical diagnosticSelf-healing hydrogelsHeavy metals

摘要: Synthetic biology is strongly inspired by concepts of engineering science and aims at the design generation artificial biological systems in different fields research such as diagnostics, analytics, biomedicine, or chemistry. To this aim, synthetic uses an approach relying on a toolbox molecular sensors switches that endows cellular hosts with non-natural computing functions circuits. Importantly, concept not only limited to approaches. building blocks have also conferred sensing switching capability otherwise inactive materials. This principle has attracted high interest for development biohybrid materials capable responding specific stimuli, disease biomarkers, antibiotics, heavy metals. Moreover, interconnection individual sense-and-respond complex enabled processing of, example, multiple inputs amplification signals using feedback topologies. Such holding potential applications analytical diagnostic sectors will be described chapter.

参考文章(187)
Keith Pardee, Alexander A. Green, Tom Ferrante, D. Ewen Cameron, Ajay DaleyKeyser, Peng Yin, James J. Collins, Paper-based synthetic gene networks Cell. ,vol. 159, pp. 940- 954 ,(2014) , 10.1016/J.CELL.2014.10.004
Simona Mura, Julien Nicolas, Patrick Couvreur, Stimuli-responsive nanocarriers for drug delivery Nature Materials. ,vol. 12, pp. 991- 1003 ,(2013) , 10.1038/NMAT3776
Raphael J. Gübeli, Désirée Hövermann, Hanna Seitz, Balder Rebmann, Ronald G. Schoenmakers, Martin Ehrbar, Ghislaine Charpin-El Hamri, Marie Daoud-El Baba, Martin Werner, Martin Müller, Wilfried Weber, Remote‐Controlled Hydrogel Depots for Time‐Scheduled Vaccination Advanced Functional Materials. ,vol. 23, pp. 5355- 5362 ,(2013) , 10.1002/ADFM.201300875
Baojun Wang, Mauricio Barahona, Martin Buck, A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals Biosensors and Bioelectronics. ,vol. 40, pp. 368- 376 ,(2013) , 10.1016/J.BIOS.2012.08.011
Constantinos Tsitsilianis, Responsive reversible hydrogels from associative “smart” macromolecules Soft Matter. ,vol. 6, pp. 2372- 2388 ,(2010) , 10.1039/B923947B
Georgyi V. Los, Lance P. Encell, Mark G. McDougall, Danette D. Hartzell, Natasha Karassina, Chad Zimprich, Monika G. Wood, Randy Learish, Rachel Friedman Ohana, Marjeta Urh, Dan Simpson, Jacqui Mendez, Kris Zimmerman, Paul Otto, Gediminas Vidugiris, Ji Zhu, Aldis Darzins, Dieter H. Klaubert, Robert F. Bulleit, Keith V. Wood, HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis ACS Chemical Biology. ,vol. 3, pp. 373- 382 ,(2008) , 10.1021/CB800025K
Hendrik W. H. van Roekel, Bas J. H. M. Rosier, Lenny H. H. Meijer, Peter A. J. Hilbers, Albert J. Markvoort, Wilhelm T. S. Huck, Tom F. A. de Greef, Programmable chemical reaction networks: emulating regulatory functions in living cells using a bottom-up approach Chemical Society Reviews. ,vol. 44, pp. 7465- 7483 ,(2015) , 10.1039/C5CS00361J
Jason E. Kreutz, Liang Li, L. Spencer Roach, Takuji Hatakeyama, Rustem F. Ismagilov, Laterally mobile, functionalized self-assembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: characterization and testing with membrane protein crystallization. Journal of the American Chemical Society. ,vol. 131, pp. 6042- 6043 ,(2009) , 10.1021/JA808697E
Dieter Klemm, Brigitte Heublein, Hans-Peter Fink, Andreas Bohn, Cellulose: Fascinating Biopolymer and Sustainable Raw Material Angewandte Chemie. ,vol. 44, pp. 3358- 3393 ,(2005) , 10.1002/ANIE.200460587
Miriam Colombo, Silvia Sommaruga, Serena Mazzucchelli, Laura Polito, Paolo Verderio, Patrizia Galeffi, Fabio Corsi, Paolo Tortora, Davide Prosperi, Site-Specific Conjugation of ScFvs Antibodies to Nanoparticles by Bioorthogonal Strain-Promoted Alkyne-Nitrone Cycloaddition Angewandte Chemie. ,vol. 51, pp. 496- 499 ,(2012) , 10.1002/ANIE.201106775