The molecular basis of alpha-thalassaemia in Thailand.

摘要: The molecular basis of alpha-thalassaemia has been established in 48 Thai subjects with Hb H disease and 15 the Bart's hydrops fetalis syndrome. This study shown that this population there are at least 18 different types chromosome carrying seven independent mutations one which is a novel deletion removing entire alpha-globin gene complex. Although limited number determinants population, remarkable degree variation genetic markers flank them. These may be value establishing evolutionary history alpha-thalassaemias.