Blocking effects of hypaconitine and aconitine on nerve action potentials in phrenic nerve-diaphragm muscles of mice.
作者： M. Muroi , I. Kimura , M. Kimura
DOI: 10.1016/0028-3908(90)90069-4
关键词: Myocyte 、 Compound muscle action potential 、 Aconitine 、 Pharmacology 、 Tetrodotoxin 、 Chemistry 、 Neuromuscular junction 、 Muscle contraction 、 Phrenic nerve 、 Anesthesia 、 Electrophysiology
摘要: The mechanisms of neuromuscular blockade by hypaconitine and aconitine were investigated electrophysiologically in isolated phrenic nerve-diaphragm muscles mice. Hypaconitine (0.08-2 microM) (0.3-2 depressed the nerve-evoked twitch tension, without affecting contraction evoked stimulation muscle. At concentrations (up to 5 2 that resting membrane potential muscle cells was unchanged. (0.1-2 (2 blocked end-plate (epp), amplitude miniature epp (mepp). quantal content potentials decreased these agents parallel with decrement amplitude. nerve compound action inhibited (5 (2-10 microM), as well 1 microM tetrodotoxin (TTX). When completely aconitine, unaffected, although TTX suppressed both same degree. These results indicate produced caused reducing release. mechanism this effect attributed mainly blocking potential.
elsevier.com
sci-hub.se 参考文章(17)
Y Ohizumi, H Nakamura, J Kobayashi, W A Catterall, Specific inhibition of [3H] saxitoxin binding to skeletal muscle sodium channels by geographutoxin II, a polypeptide channel blocker. Journal of Biological Chemistry. ,vol. 261, pp. 6149- 6152 ,(1986) , 10.1016/S0021-9258(19)84540-4
William A. Catterall, Jeffrey Coppersmith, Pharmacological properties of sodium channels in cultured rat heart cells. Molecular Pharmacology. ,vol. 20, pp. 533- 542 ,(1981)
Masayasu KIMURA, Masashi MUROI, Ikuko KIMURA, Shin-ichiro SAKAI, Isao KITAGAWA, Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-sino medicine "bushi" (aconite root). Japanese Journal of Pharmacology. ,vol. 48, pp. 290- 293 ,(1988) , 10.1254/JJP.48.290
M. Kimura, I. Kimura, T. Nakamura, H. Nojima, Diabetic state-induced modification of resting membrane potential and conductance in diaphragm muscle of alloxan and diabetic KK-CAy mice. Diabetologia. ,vol. 31, pp. 103- 107 ,(1988) , 10.1007/BF00395556
B. Katz, S. Thesleff, On the factors which determine the amplitude of the ‘miniature end-plate potential’ The Journal of Physiology. ,vol. 137, pp. 267- 278 ,(1957) , 10.1113/JPHYSIOL.1957.SP005811
I.I. Grishchenko, A.P. Naumov, A.N. Zubov, Gating and selectivity of aconitine-modified sodium channels in neuroblastoma cells Neuroscience. ,vol. 9, pp. 549- 554 ,(1983) , 10.1016/0306-4522(83)90173-2
Masayasu KIMURA, Ikuko KIMURA, Kazuyoshi TAKAHASHI, Masashi MUROI, Masao YOSHIZAKI, Matao KANAOKA, Isao KITAGAWA, Blocking Effects of Blended Paeoniflorin or Its Related Compounds with Glycyrrhizin on Neuromuscular Junctions in Frog and Mouse Japanese Journal of Pharmacology. ,vol. 36, pp. 275- 282 ,(1984) , 10.1254/JJP.36.275
Akira WARASHINA, Frequency-dependent effects of aconitine and veratridine on membrane currents in the crayfish giant axon. Japanese Journal of Physiology. ,vol. 35, pp. 463- 482 ,(1985) , 10.2170/JJPHYSIOL.35.463
B. Katz, R. Miledi, A study of synaptic transmission in the absence of nerve impulses. The Journal of Physiology. ,vol. 192, pp. 407- 436 ,(1967) , 10.1113/JPHYSIOL.1967.SP008307
T M Linder, D M Quastel, A voltage-clamp study of the permeability change induced by quanta of transmitter at the mouse end-plate. The Journal of Physiology. ,vol. 281, pp. 535- 556 ,(1978) , 10.1113/JPHYSIOL.1978.SP012438