Pituitary adenylate cyclase activating polypeptide is protective in bilateral carotid occlusion-induced retinal lesion in rats
作者： Tamás Atlasz , Norbert Babai , Péter Kiss , Dóra Reglődi , Andrea Tamás
DOI: 10.1016/J.YGCEN.2006.12.022
关键词: Neuroprotection 、 Neuropeptide 、 Outer plexiform layer 、 Internal medicine 、 Retinal degeneration 、 Biology 、 Retinal 、 In vivo 、 Neurotrophin 、 Endocrinology 、 Retina
摘要: Pituitary adenylate cyclase activating popypeptide (PACAP) is a pleiotropic neuropeptide, exerting neurotrophic and neuroprotective effects in numerous models of vitro vivo nervous injuries. The aim the present study was to investigate whether PACAP ischemic retinal damage. Adult male Wistar rats underwent bilateral carotid occlusion administered unilaterally into vitreous body immediately following occlusion. Retinas were analyzed three weeks after injury. It found that led severe degeneration all layers. treatment significantly ameliorated occlusion-induced damage: overall thickness retina more than control occluded animals morphological characteristics photoreceptors showed nearly normal appearance. outer plexiform layer remained discernible inner nuclear layers thicker animals. In summary, our provides evidence, for first time, attenuates degeneration.
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