pT4 stage II and III colon cancers carry the worst prognosis in a nationwide survival analysis. Shepherd's local peritoneal involvement revisited.

摘要: The aim of this study is to clarify the prognostic importance several well-known but still debated pathological variables related survival colon cancer patients. focuses on definition and carried by pT4 category stage II where presence high-risk may determine whether or not adjuvant chemotherapy administered. A retrospective nationwide was out including all patients that underwent resection in Iceland between 1990 2004 (n = 889). All histopathology reassessed. Cancer-specific (CSS) overall were analysed using Kaplan-Meier Cox regression analysis. In II, five-year CSS for 50% (95% CI, 32–69%), which lowest observed stage. III 30% 18–41%) 37% 26–48%) pN2 tumors, respectively. Lymphatic invasion differentiation had no value II. associated with pT4a versus pT4b depends how these categories are defined regard Shepherd's local peritoneal involvement (LPI). present series, a major indicator poor prognosis carcinoma. Four-tiered TNM Dukes staging systems insufficient taking variable into account. Only LPI4 subgroup LPI3 (i.e., borderline LPI3/LPI4) should qualify subcategory. results do support lymphatic as variables.