MUC16: molecular analysis and its functional implications in benign and malignant conditions

摘要: MUC16 is a high-molecular-weight glycoprotein that expressed by the various epithelial cell surfaces of human body to protect layer from myriad insults. It largest mucin known date, with an ∼22,152 aa sequence. Structurally, characterized into 3 distinct domains: amino terminal, tandem repeat, and carboxyl terminal domain, each domain having unique attributes. The extracellular portion shed bloodstream serves as biomarker for diagnosing monitoring patients cancer; however, its functional role in cancer yet be elucidated. Several factors contribute this challenge, which include large protein size; extensive glycosylation undergoes, confers heterogeneity; lack specific antibodies detect domains MUC16; existence splicing variants. Despite these limitations, has been established molecule significant application cancer....