Blood levels of microRNAs associated with ischemic heart disease differ between Austrians and Japanese: a pilot study

摘要: Mortality from ischemic heart disease (IHD) is significantly lower in Japan than Western countries. The purpose of this study was to investigate differences circulating microRNA (miRNA) levels related IHD Austrians and Japanese. Participants were middle-aged healthy male (n = 20) Japanese (n = 20). Total miRNAs serum each participant analyzed using the 3D-Gene miRNA Oligo chip. Twenty-one miRNAs, previously reported as associated with IHD, compared between expression miR-106a-5p, miR-135a-3p, miR-150-3p, miR-16-5p, miR-17-5p. miR-191-5p, miR-320b, miR-451a, miR-486-5p, miR-663b, miR-92a-3p higher, while miR-2861 level Both Japanese, there significant positive correlations pair above except for miR-2861. showed miR-17-5p, miR-663b but not In pathway analysis, proinflammatory cytokine production foam cells collagen synthesis vascular smooth muscle differentially expressed miRNAs. Difference may contribute cardiovascular risk