Comparative chemical structure and pharmacokinetics of MRI contrast agents.

摘要: The blood clearance kinetics of five gadolinium complexes, Gd(L), were determined in rats and the results interpreted terms an open two-compartment pharmacokinetic model. complexes tested vitro for stability serum aqueous solutions ions that they might encounter vivo be expected to react with Gd(L) produce uncomplexed gadolinium. Reaction was observed two instances. Chemical structural differences among chelating ligands appear govern overall reactivity their complexes. It may inferred from a preferred feature ligand is presence 12-membered 1,4,7,10-tetraaza macrocycle.