Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial

摘要: Abstract Background Computerized cognitive rehabilitation training (CCRT) may be beneficial for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors. We completed a randomized controlled trial of CCRT both and non-malaria cohorts children. Methods 150 school-age children were to three treatment arms: 24 sessions Captain’s Log attention, working memory nonverbal reasoning, which on each 9 tasks difficulty increased with proficiency; limited arm that did not titrate proficiency but randomly cycled across the simplest moderate level training; passive control arm. Before after 2 months intervention one year following, tested Kaufman Assessment Battery Children, 2nd edition (KABC-II), computerized CogState tests, Behavior Rating Inventory Executive Function (BRIEF), Achenbach Child Checklist (CBCL). Results Malaria assigned limited-CCRT significantly better than controls KABC-II Mental Processing Index (P = 0.04), Sequential (working memory) (P = 0.02) Conceptual Thinking subtest (planning/reasoning) (P = 0.02). At post-training, had more rapid card detection (attention) (P = 0.02), improved BRIEF Global (P = 0.01) as compared controls. Non-malaria receiving benefited only (both full- limited-CCRT; P  Conclusion For survivors, attention outcomes full CCRT, perhaps because greater repetition practice relevant absence performance titration CCRT. There fewer significant behavior benefits children, exception planning/reasoning Thinking, stronger improvements one-year follow-up.