Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5-HT.

摘要: Clonazepam is a potent anticonvulsant 1,4-benzodiazepine that controls some types of myoclonus. Its primary mode action to facilitate GABAergic transmission in the brain by direct effect on benzodiazepine receptors. GABA receptors lie cell bodies dorsal raphe neurons, and acts inhibit firing, an potentiated benzodiazepines. does not alter 5-HT synthesis but decreases utilization blocks egress 5-HIAA from brain. It known whether actions clonazepam altering function are responsible for its antimyoclonic action, since these observed only after large doses. Also, effects exact opposite those predicted beneficial 5-HTP human myoclonic disorders. Finally, why clonazepam, more than other benzodiazepines, benefit treatment myoclonus clear. This may be due pharmacokinetic feature drug conjunction with potency at