The contribution of inherited predisposition to cancer incidence.

摘要: Only a small proportion of cancers, arising in inherited syndromes such as polyposis coli, have an unequivocally basis. Nevertheless, most common cancers show familial clustering, much which may be due to predisposition. If so, there wide variation genetic susceptibility cancers. The precise models are unclear, but for ovarian cancer and breast is some evidence that cases result from highly penetrant dominant genes. This has been confirmed recently by linkage studies. Clear obtained Hodgkin's disease nasopharyngeal carcinoma, where the existence genes at HLA locus demonstrated analysis. These could account majority these Identification other should possible, either directly using analysis, or through identification constitutional phenotypes related risk.