Evidence of complement catabolism in experimental acute pancreatitis.

摘要: Serum specimens from guinea pigs with experimentally induced acute pancreatitis were examined for evidence of protease-antiprotease imbalance and complement catabolism. Pancreatitis was in 22 male Hartley by the injection sodium taurocholate into pancreatic parenchyma. Only a laparotomy performed 6 control animals. In 10 experimental animals that survived less than 24 hours, there significant, early reduction serum trypsin inhibitory capacity (a measure antiprotease activity). Levels total hemolytic as well titers C3 C4 fell significantly all during first hours. Factor B activity, however, did not change. contained chemotactic activity human polymorphonuclear leukocytes. These findngs indicate circulating components are cleaved course pancreatitis. As consequence, complement-derived peptides generated may mediate local systemic tissue injury.