Phase II trial of docetaxel in patients with advanced cutaneous malignant melanoma previously untreated with chemotherapy.
作者： A Y Bedikian , G R Weiss , S S Legha , H A Burris , J R Eckardt
DOI: 10.1200/JCO.1995.13.12.2895
关键词: Docetaxel 、 Metastasis 、 Brain metastasis 、 Phases of clinical research 、 Medicine 、 Gastroenterology 、 Internal medicine 、 Neutropenia 、 Chemotherapy 、 Toxicity 、 Melanoma 、 Surgery
摘要: PURPOSEA phase II study was undertaken to determine the efficacy of docetaxel in patients with metastatic malignant melanoma.PATIENTS AND METHODSBetween June 1992 and March 1994, 40 melanoma no prior chemotherapy were treated 100 mg/m2 administered intravenously over 1 hour every 21 days. None had brain metastasis. Toxicity follow-up data are provided.RESULTSOne patient a histologically confirmed complete response that lasted for 14+ months. Four partial responses, bringing overall rate 12.5% (95% confidence interval [CI], 6% 30%). A single chest-wall metastasis rendered free disease surgically after maximal remained tumor recurrence 18+ Tumor stabilized 22 patients. The median survival time 13 main hematologic toxicity neutropenia, which severe but transient. P...
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