Accelerated Aging in HIV Patients.
作者： Keren Meir-Shafrir , Shimon Pollack
DOI: 10.5041/RMMJ.10089
关键词: Viral load 、 Cart 、 T cell 、 Physiology 、 Acquired immunodeficiency syndrome (AIDS) 、 Bioinformatics 、 Accelerated aging 、 Neurocognitive 、 Life expectancy 、 Medicine 、 Immune system
摘要: Life expectancy has been increasing in the last few decades Western world and is accompanied by higher occurrence of age-related diseases like metabolic, cardiovascular, renal also with a decline immune functions. In HIV-infected people, due to use combination antiretroviral therapy (cART), life increased. As result, non-AIDS conditions which are age-associated have become more prevalent appear earlier, resulting accelerated aging HIV patients. These patients associated CD4+ T cell counts: lower counts rates liver, renal, neurocognitive disorders. The effect viral load cART on earlier less significant than CD4 count effect. Thus, loss functions may enhance aging.
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