Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival

摘要: Patients with glioblastoma (GBM) have variable clinical courses, but the factors that underlie this heterogeneity are not understood. To determine whether presence of telomerase-independent alternative lengthening telomeres (ALTs) mechanism is a significant prognostic factor for survival, we performed retrospective analysis 573 GBM patients. The ALT was identified in paraffin sections using combination immunofluorescence promyelocytic leukemia body and telomere fluorescence situ hybridization. Alternative present 15% had longer survival independent age, surgery, other treatments. Mutations isocitrate dehydrogenase ( IDH1 mut) 1 frequently accompanied ALT, both molecular events, there significantly overall survival. These data suggest most ALT+ tumors may be less aggressive proneural GBMs, better prognosis relate to set genetic changes associated tumor subtype. Despite improved patients treated addition chemotherapy radiotherapy independently provided advantage, these were found additive. results critical need developing new therapies target specific subtypes.