Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson's disease.

摘要: Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed to examine whether MBs are associated motor or decline Parkinson’s disease (PD). enrolled 135 PD and 34 healthy controls. All participants underwent brain MRI plasma biomarker assays, including tau, Aβ42, Aβ40, α-synuclein. dementia (PDD) was operationally defined as Mini-Mental State Examination (MMSE) score < 26 advanced stage Hoehn-Yahr stage ≥ 3 during “on” status. The association between severity examined using multivariate logistic regression models. More lobar were observed than controls (20.7% vs. 3.3%, p = 0.031). PDD had more (33.3% 15.6%, p = 0.034), white matter hyperintensity (p = 0.021) reduced hippocampal volume (p = 0.001) normal cognition. presence of MB (odds ratio = 2.83 [95% confidence interval 1.04–7.70], p = 0.042) severe (3.29 [1.21–8.96], p = 0.020) independently after adjusting for vascular risk factors other confounders. Furthermore, Aβ40 levels the MMSE score (p = 0.004) age sex. Our findings demonstrated that MBs, volume, elevated PDD.