Is There Specificity Involved in Fcε Receptor Aggregation Which Leads to an Effective Secretory Stimulus

摘要: Immunological stimulation of mast cells and basophils to secretion mediators the immediate-type hypersensitivity is initiated by antigen induced aggregation “high-affinity” receptor for Fce (FceRI) (Ishizaka Ishizaka 1984; Froese Metzger et al 1986). The specificity this stimulus provided IgE class antibodies which are bound FceRI probably their Fce2 Fce3 domains (Helm 1988). This cell-membrane antibody — binding crosslinking process, initiates secretory response, rather interesting its own sake yet also a useful paradigm many other cell-stimulatory processes upon aggregation. Hence, extensive theoretical experimental work has been done in order obtain detailed physicochem- ical understanding triggering process. Still goal so far only partly attained (De Lisi Siraganian 1979; Ishizaka,