Antimicrobial function of human saliva - how important is it for oral health?

摘要: Human saliva contains a number of physical physicochemical, and chemical agents that protect oral tissues against noxious compounds, in particular those produced by various microorganisms. Among such protective factors, the flushing effect flow is most important one, not only because it so effectively removes exogenous endogenous microorganisms their products into gut but also steady supply guarantees continuous presence both non-immune immune factors mouth. A great studies with controversial results have been published regarding individual possible association to health, particularly dental caries. It appears no single agent far more than others. For example, patients selective IgA deficiency normal levels defense often display compensatory increase other immunoglobulin isotypes. The concerted action all whole saliva, saliva- serum-derived, provides multifunctional network collapsed if salivary rate substantially reduced. In this mixture many show additive or even synergistic interactions pathogens. Increased knowledge molecular functions has made prepare hygiene product include host-derived antimicrobial instead synthetic agents. Although clinical efficacy still unsatisfactory poorly described, new technologies, for example production specific antibodies pathogens, may considerably improve power these products.