Systematic Studies of Dopamine and Dopamine-Derived Salsolinol and Norsalsolinol levels in Various Human Brain Areas
作者： Frank Musshoff , Peter Schmidt , Reinhard Dettmeyer , Fritz Priemer , Holger Wittig
DOI: 10.1007/978-1-4615-1269-1_10
关键词: Stereochemistry 、 In vivo 、 Ethanol 、 Decarboxylation 、 Dopamine 、 Pyruvic acid 、 Chemistry 、 Racemic mixture 、 Acetaldehyde 、 Norsalsolinol
摘要: Similarities between alcoholism and morphinism concerning the development of an addiction symptoms withdrawal led to hypothesis that opiate-active compounds might be formed endogenously during establishment alcohol (Huber Melzig, 1992). This theory was supported by proof in vivo formation various alkaloids human body. One invoked ethanol metabolite acetaldehyde as a critical intermediate biosynthesis compounds. Acetaldehyde can condense directly with catecholamines tissues form substituted 6,7-dihydroxy-l,2,3,4-tetrahydroisoquinolines, most discussed compound being salsolinol (SAL). SAL non-enzymatic ring cyclization dopamine (DA) oxidation product yield racemic mixture both, (R)- (S)-enantiomer. Another pathway is condensation pyruvic acid, followed enzymatic decarboxylation reduction.
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