Deferoxamine-induced electronegative ERG responses
作者： Ruben Jauregui , Karen Sophia Park , Alexander G. Bassuk , Vinit B. Mahajan , Stephen H. Tsang
DOI: 10.1007/S10633-018-9640-3
关键词: Erg 、 Electroretinography 、 Atrophy 、 Retinopathy 、 Retinal pigment epithelium 、 Nyctalopia 、 Medicine 、 Ophthalmology 、 Retinal 、 Visual acuity
摘要: To report a case of deferoxamine-induced retinopathy characterized by electroretinography (ERG), optical coherence tomography angiography (OCT-A), and other multimodal imaging. This is an observational one patient. Full-field ERG was performed. OCT-A, spectral-domain (SD-OCT), color fundus photography, autofluorescence were used to characterize the induced deferoxamine use. A 64-year-old man with history β-thalassemia intermedia presented worsening visual acuity, nyctalopia, electronegative ERG. OCT-A revealed atrophy choriocapillaris in areas hypoautofluorescence, corresponding regions retinal atrophy. SD-OCT showed disruption ellipsoid zone, granular hyperreflective deposits within pigment epithelium, thinning layers, extensive choroidal sclerosis epithelium. Deferoxamine-induced can manifest maximal responses, be detect toxicity.
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sci-hub.se 参考文章(20)
Maura Di Nicola, Giulio Barteselli, Laura Dell’Arti, Roberto Ratiglia, Francesco Viola, Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature BioMed Research International. ,vol. 2015, pp. 249617- 249617 ,(2015) , 10.1155/2015/249617
Robert Haimovici, Donald J D’Amico, Evangelos S Gragoudas, Samuel Sokol, Deferoxamine Retinopathy Study Group, The expanded clinical spectrum of deferoxamine retinopathy. Ophthalmology. ,vol. 109, pp. 164- 171 ,(2002) , 10.1016/S0161-6420(01)00947-2
Alexa Klettner, Stefan Koinzer, Vicki Waetzig, Thomas Herdegen, Johann Roider, Deferoxamine mesylate is toxic for retinal pigment epithelium cells in vitro, and its toxicity is mediated by p38. Cutaneous and Ocular Toxicology. ,vol. 29, pp. 122- 129 ,(2010) , 10.3109/15569521003745685
Wei Wang, Mary Ann Knovich, Lan G. Coffman, Frank M. Torti, Suzy V. Torti, Serum ferritin: Past, present and future. Biochimica et Biophysica Acta. ,vol. 1800, pp. 760- 769 ,(2010) , 10.1016/J.BBAGEN.2010.03.011
Francesco Viola, Giulio Barteselli, Laura Dell'Arti, Diego Vezzola, Edoardo Villani, Chiara Mapelli, Laura Zanaboni, Maria D. Cappellini, Roberto Ratiglia, Abnormal Fundus Autofluorescence Results of Patients in Long-term Treatment with Deferoxamine Ophthalmology. ,vol. 119, pp. 1693- 1700 ,(2012) , 10.1016/J.OPHTHA.2012.01.039
Shantan Reddy, Diana Iturralde, Catherine Meyerle, Nicole E Gross, Lawrence A Yannuzzi, None, Fundus autofluorescence in retinopathy caused by deferoxamine toxicity. Retinal Cases & Brief Reports. ,vol. 1, pp. 120- 122 ,(2007) , 10.1097/01.ICB.0000279640.76453.EB
Isabelle Audo, Anthony G. Robson, Graham E. Holder, Anthony T. Moore, The negative ERG: clinical phenotypes and disease mechanisms of inner retinal dysfunction. Survey of Ophthalmology. ,vol. 53, pp. 16- 40 ,(2008) , 10.1016/J.SURVOPHTHAL.2007.10.010
Cheng-Hsiu Wu, Chao-Ping Yang, Chi-Chun Lai, Wei-Chi Wu, Yi-Hsing Chen, Deferoxamine retinopathy: spectral domain-optical coherence tomography findings. BMC Ophthalmology. ,vol. 14, pp. 88- 88 ,(2014) , 10.1186/1471-2415-14-88
Christina Zeitz, Anthony G. Robson, Isabelle Audo, Congenital stationary night blindness: an analysis and update of genotype-phenotype correlations and pathogenic mechanisms. Progress in Retinal and Eye Research. ,vol. 45, pp. 58- 110 ,(2015) , 10.1016/J.PRETEYERES.2014.09.001
Gary M. Brittenham, Iron-Chelating Therapy for Transfusional Iron Overload The New England Journal of Medicine. ,vol. 364, pp. 146- 156 ,(2011) , 10.1056/NEJMCT1004810