In vivo SPECT imaging of vesicular acetylcholine transporter using [123I]-IBVM in early Alzheimer's disease

摘要: Abstract Introduction Little is known about cholinergic activity in the early stage of Alzheimer's disease. We investigated differences distribution vesicular acetylcholine transporter, using [ 123 I]-iodobenzovesamicol ([ I]-IBVM) and Single Photon Computed Tomography (SPECT), AD age-matched controls. Materials methods Sixteen subjects (8 controls, 8 AD) underwent I]-IBVM SPECT scanning, T1-weighted anatomic scan by Magnetic Resonance (MR) imaging Mini-Mental State Evaluation (MMSE). Image analysis, Statistical Parametric Mapping (SPM 02), involved coregistration each image to MR scan, followed a spatial normalisation Montreal Neurological Institute standard brain smoothing image. Group effects correlation were assessed two sample t -tests linear regression respectively. Atrophy difference between groups was voxel-based morphometry -tests. Results MMSE values significantly different Relative significant decrease binding (47–62%) apparent cingulate cortex parahippocampal–amygdaloid complex. These patterns appeared be independent atrophied areas. Conclusion results strongly suggest that degeneration occurs could impairment cognitive functions. Imaging neurons used here effective identifying potential treatment responders.