Controlled trial of synthetic D-penicillamine and prednisone in maintenance therapy for active chronic hepatitis.
作者： R B Stern , S P Wilkinson , P J Howorth , R Williams
DOI: 10.1136/GUT.18.1.19
关键词: Disease 、 Physical therapy 、 Prednisone 、 Hepatitis 、 Internal medicine 、 Active chronic hepatitis 、 Maintenance therapy 、 Randomized controlled trial 、 Penicillamine 、 Liver function tests 、 Medicine 、 Gastroenterology
摘要: In view of promising, but uncontrolled, reports the use D-penicillamine in active chronic hepatitis, a randomised, prospective, controlled trial this drug against prednisone was carried out. Of 35 patients entered, 18 received (increasing to 1-2 g daily) and 17 (15 mg daily). all disease had already been brought under biochemical control with corticosteroids. During first year trial, treatment nine group discontinued (two because lack seven side-effects) compared six (four control, one side-effects, development carcinomatosis. Detailed statistical analysis liver function tests remaining at end showed no significant differences. is associated higher frequency side-effects than prednisone. However, some it as satisfactory keeping control.
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