NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1.
作者： Arthur Pardi , Xiao Lu Zhang , Michael E. Selsted , Jack J. Skalicky , Ping F. Yip
DOI: 10.1021/BI00161A013
关键词: Molecular dynamics 、 Stereochemistry 、 Defensin 、 Nuclear magnetic resonance spectroscopy 、 Molecule 、 Antiparallel (biochemistry) 、 Antimicrobial peptides 、 Protein structure 、 Chemistry 、 Peptide
摘要: The solution structure of two homologous naturally occurring antimicrobial peptides, rabbit defensin NP-2 and human HNP-1, have been determined by two-dimensional nuclear magnetic resonance spectroscopy, distance geometry, restrained molecular dynamics calculations. these defensins consists an antiparallel beta-sheet in a hairpin conformation, short region triple-stranded beta-sheet, several tight turns, loop that has well-defined local but with global orientation is not respect to the rest molecule. structures peptides are compared crystal other defensins. for also known peptides.
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