Elimination of Dog-Mediated Human Rabies Deaths by 2030: Needs Assessment and Alternatives for Progress Based on Dog Vaccination.

摘要: Background. Rabies imposes a substantial burden to about half of the world population. The World Health Organization (WHO), for Animal Health, and Food Agriculture Organization, have set goal eliminating dog-mediated human rabies deaths by 2030. This could be achieved largely massive administration post-exposure prophylaxis –in perpetuity–, through elimination dog rabies, or combining both. Here we focused on resources needed virus Materials methods. Drawing from multiple datasets, including national vaccination campaigns, literature, expert opinion, developed model considering country-specific current capacity estimate years required achieve elimination. Resources were determined based four factors: a) country development status, b) costs, c) vaccine availability, d) existing animal health workers. Our calculations WHO’s that vaccinating 70% population seven consecutive would eliminate rabies. Findings. If production remains at 2015 levels, there will cumulative shortage 7.5 billion doses meet expected demand We estimated present cost $6,300 million (m) in all endemic countries, equivalent $3,900m gap compared spending. To workforce may suffice if public veterinarians countries dedicate three months each year vaccination. discuss implications technology improvements, management, price reduction, increases dog-vaccinating capacities. Conclusion. results highlight As exemplified successful disease efforts, one size does not fit all. suggest pragmatic feasible options towards global 2030, while identifying several benefits drawbacks specific approaches. hope these help stimulate inform necessary discussion regional strategic planning, resource mobilization, continuous execution