Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

摘要: PARTICLE_RISK was one of the first multidisciplinary projects funded by European Commission’s Framework Programme that responsible for evaluating implications nanomaterial (NM) exposure on human health. This project basis this review which identifies challenges exist within assessment NM risk. We have retrospectively reflected findings completed nanotoxicology studies to consider what progress and advances been made risk NMs, as well discussing direction research is taking identifying limitations failings existing research. commonly encountered explored how these issues may be resolved. In particular, following discussed (i) selection (ii) physico-chemical characterisation; (iii) dispersion; (iv) relevant doses concentrations; (v) identification models, target sites endpoints; (vi) develo...