Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A Polymorphisms Are Associated with the Risk of Esophageal Cancer in a Chinese Population

摘要: Esophageal cancer is the eighth most common and sixth leading cause of associated death worldwide. Besides environmental risk factors, genetic factors might play an important role in esophageal carcinogenesis. We conducted a hospital based case–control study to evaluate susceptibility functional single nucleotide polymorphisms (SNPs) microRNAs on development cancer. A total 629 squamous cell carcinoma (ESCC) cases 686 controls were recruited for this study. The hsa-miR-34b/c rs4938723 T>C, pri-miR-124-1 rs531564 C>G, pre-miR-125a rs12975333 G>T hsa-miR-423 rs6505162 C>A genotypes determined using Ligation Detection Reaction (LDR) method. Our results demonstrated that CC genotype had decreased ESCC. association was evident among patients who never drinking. Hsa-miR-423 with significantly increased ESCC smoking. These findings indicated T>C alter individual However, our obtained limited sample size. Future larger studies other ethnic populations are required confirm current findings.